Adrian has retained his place in goal in David Moyes' team to face Chelsea on Saturday afternoon.
The Hammers No13 performed superbly at Manchester City last week when Joe Hart was unavailable due to the terms of his loan, but the England keeper has been unable to dislodge Adrian from the starting position.
Winston Reid also returns to the team after missing the trip to Etihad Stadium with injury, and he lines up alongside Angelo Ogbonna at centre-back.
Marko Arnautovic is also back in after he was amongst the substitutes against Man City, while Mark Noble starts in central midfield after overcoming a hip injury.
Chicharito is also available again and is on a very attacking bench, alongside Andy Carroll, Diafra Sakho and Andre Ayew.
West Ham United: Adrian, Zabaleta, Reid, Ogbonna, Cresswell, Noble (c), Obiang, Arnautovic, Lanzini, Masuaku, Antonio
Subs: Hart, Rice, Fernandes, Ayew, Carroll, Sakho, Chicharito
Chelsea: Courtois, Azpilicueta, Christiansen, Cahill (c), Zappacosta, Kante, Bakayoko, Alonso, Fabregas, Hazard, Morata
Subs: Caballero, Rudiger, Moses, Willian, Ampadu, Pedro, Batshuayi
Referee: Anthony Taylor