Jose Fonte and Portugal made a drawing start to their FIFA Confederations Cup campaign when they were twice pegged back by Mexico on Sunday afternoon.
Portugal will be disappointed to not have taken maximum points in Kazan, after Ricardo Quaresma and Cedric Soares gave them the lead in both halves.
Southampton's Soares' goal, just four minutes from time, looked to have secured a 2-1 victory, but Hector Moreno nodded home a leveller in stoppage time.
Former Manchester United forward Javier Hernandez had earlier cancelled out Quaresma's clever opener.
Fonte played the 90 minutes alongside Pepe at centre back to earn his 24th Portugal cap.
Portugal sit level with Mexico in joint-second in Group A after their first game, with Russia beating New Zealand 2-0 in Saturday's opening fixture.
The Portuguese are back in action on Wednesday when they take on the hosts Russia.